579 In vitro activity of efinaconazole against terbinafine and itraconazole resistant and susceptible dermatophyte, candida, and mold clinical isolates

Recently, numerous cases of dermatophytosis resistant to terbinafine were reported. These have been increasing in frequency, with no improvement even treatment using systemic therapies. Our objective was determine the antifungal activity efinaconazole compared fluconazole, itraconazole, and against dermatophyte, Candida, mold clinical isolates In vitro. Activity antifungals assessed minimum inhibitory concentration(MIC) fungicidal concentration(MFC). Isolates tested included susceptible Trichophyton mentagrophytes (n=16), T. rubrum(n=43), tonsurans (n=18), violaceum (n=4), Candida albicans (n=55), C. auris (n=30), Fusarium sp., Scedosporium Scopulariopsis sp. (n=15 for each). Against dermatophytes, most active other agents MIC50 MIC90 (Concentration that inhibited 50% 90% strains tested, respectively) 0.002 0.03 μg/ml, respectively. While itraconazole showed 1 8 0.25 0.031 16 isolates, 0.016 contrast, had 0.5 2 different species, MIC ranged between a range from higher than 64 μg/ml comparators. conclusion potent broad panel dermatophyte isolates. Furthermore, Efinaconazole demonstrated high